A pore-forming toxin enablesSerratiaa nonlytic egress from host cells
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منابع مشابه
Lysenin: a sphingomyelin specific pore-forming toxin.
Sphingomyelin is a major sphingolipid in mammalian cells. Recent results indicate that sphingomyelin is a reservoir of lipid second messengers, ceramide and sphingosine-1-phosphate. Sphingomyelin is also a major component of sphingolipid and cholesterol-rich membrane domains (lipid rafts). Lysenin is a pore-forming toxin that specifically binds sphingomyelin. The binding of lysenin to sphingomy...
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Y. Tanaka and M. Yao (Hokkaido Univ.) Pathogenic bacteria express pore-forming toxins (PFTs) to attack host cells. PFTs are expressed as soluble monomeric proteins, which assemble to prepore oligomer on the target cells. After forming prepore, conformational change occurs, and then the pore is formed. Although the crystal structures of monomer and pore have been determined, the detailed mechani...
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Pseudomonas entomophila is an entomopathogenic bacterium that infects and kills Drosophila. P. entomophila pathogenicity is linked to its ability to cause irreversible damages to the Drosophila gut, preventing epithelium renewal and repair. Here we report the identification of a novel pore-forming toxin (PFT), Monalysin, which contributes to the virulence of P. entomophila against Drosophila. O...
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Program in Molecular and Cellular Biology DEDICATION TO MY CARING GRANDMOTHER iv ACKNOWLEDGEMENT I take this page to thank everyone who was involved directly or indirectly in this project. To my advisor, Dr. Min Chen, who has given me the chance to work under her experienced guidance and supervision. I would like to also thank the rest of my committee members, Dr. Ludmila Tyler and Dr. David Gr...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2016
ISSN: 1462-5814
DOI: 10.1111/cmi.12656